So, it seems that generating antibodies particularly for viruses/Mycoplasma/bacteria which cannot be vaccinated — is inevitable. You need to prepare for it. "Why should I prepare if infection is inevitable?" Some might wonder. Remember COVID: Preventive measures. Identifying the Pathogen Comes First—Key in This Context. Rapid testing was crucial under COVID. Knowing what you have helps decide the next course of action: don't push through illness, rest; fever is likely — stock up on antipyretics and oximeters/critical medicines for elderly at home. Being prepared and comprehensive is important. Drawing from clinical practice plus my own parenting during this “immune debt”, here are three steps to action: Step 1: Track weekly epidemic reports. This helps to recognize circulating pathogens beforehand. The weekly epidemic data is mostly available on local CDC websites. For instance: In the Beijing CDC's Week 47 (Nov 20–26,2023), a total of 72,475 cases in 16 notifiable diseases were reported. Influenza, COVID-19, hand-foot-mouth disease (HFMD), infectious diarrhea and syphilis were the top five diseases — accounting for 99.4% of cases. Main points: - Review recent (last 1-4 weeks) reports. - Large no. of cases indicate ongoing transmission - Regional risk (e.g., flu and COVID-19 are presently circulating in Beijing). Step 2: Know how to respond for prevalent pathogens. Among these, key ones for autumn and winter 2023 through spring 2024 are: - Influenza A/B: Get vaccinated first; multiple subtypes make prevention difficult but usually it resolves with fluids and fever control. Persistent fever/cough needs medical attention. - Mycoplasma pneumoniae: There are treatments available, but the key is early intervention. - Respiratory syncytial virus (RSV)/**Adenovirus**: Self-resolving; antivirals not recommended in most cases. - Rhinovirus: Usually mild with nasal symptoms. Step 3: Stay calm and plan your actions if infected Most viruses self-limit. The immune system 's workout is a fever. If your symptoms suggest Mycoplasma (e.g., dry cough, high fever) or don't resolve: - No online diagnosis based off your symptoms at home. - Head to the nearest clinic for specific tests such as CBC, CPR and respiratory pathogen panel. - Diagnose and confirm, then proceed with targeted treatment. Don't hit the hospital unless you have to: cross-infection risk > benefit (clinics generally offer same diagnostics/treatment).